SAM-e

by PhysioLogics

S-Adenosyl-methionine (SAMe) is formed by combining L-methionine with ATP (adenosine triphosphate) the body's primary energy molecule for fueling the heart and other major organs. It was discovered by scientists in Italy in 1952, and after more than 40 years of use in Europe, SAMe remains the safest, active and efficient methyl donor known.

SAMe is involved in a complex series of biochemical pathways in the human body. It functions as a methyl donor in the transmethylation process and is also involved in transsulfuration and aminopropytation pathways.

As a methyl donor, SAMe adds a single carbon unit to another molecule a process known as transmethylation. SAMe transfers its S-methyl group to the brain and nerve sheaths to protect the synthesis of phospholipids and neurotransmitters. Experts theorize that this methylation process increases levels of mood-elevating neurotransmitters such as serotonin and dopamine, and also increases phosphatidylserine levels which can have a dramatic effect on mood.

By releasing its methyl groups, SAMe also becomes part of another complex pathway the transsulfuration process. As part of this process, SAMe becomes a critical component for the synthesis of all sulfur-containing compounds in the body, including glutathione and taurine. Glutathione is one of the body's most important endogenous antioxidants, and both glutathione and taurine are critical for the liver's detoxification process. Some of the sulfur from this process is also used to build connective tissue such as cartilage, ligaments, and tendons, and help form strong joints.

Aminopropytation (or polyamine synthesis) also occurs with SAMe. Aminopropytation produces substances known as polyamines, which play an important role in cell and tissue growth. A by-product of the production of these polyamines is a natural chemical known as methylthioadenosine (MTA) the body's 'communication mechanism' for transferring pain and inflammation messages to the brain. This process may also contribute to SAMe's benefits for joint health.

Supplementing SAMe is important because it is not easily obtained from food, and the availability of this important molecule decreases with age. Long-term clinical trials in Europe have found that SAMe is safe and suitable for long-term supplementation.

Because SAMe is a highly reactive molecule, PhysioLogics has subjected its product to rigorous quality assurance testing methods. PhysioLogics' SAMe is manufactured under strict climate controls and blended, compressed, and enterically coated the same day to minimize degradation. We further test the enteric coating for disintegration using current USP methods, run a post-tablet concentration evaluation using HPLC technology, and check for degradants and friability (brittleness) in the tablets.

SAMe's benefits include:

• Increasing levels of mood-enhancing neurotransmitters in the brain
  

• An important component of healthy joints and tissue
  

• Used in Europe for over 40 years with very few side effects
  

• Enterically coated and tested for stability at doses of 1200-1600 mg per day*
  

Two tablets contain: S-adenosylmethionine (SAM-e) 400 mg.

Other ingredients: Cellulose (Plant Origin), Croscarmellose, Vegetable Magnesium Stearate, Magnesium Silicate, Silica, Methacrylic Acid Copolymer.

Suggested use: For adults, we recommend taking two (2) tablets daily, preferably on an empty stomach. In order to obtain maximum benefits, SAM-e should be taken at least 30 minutes prior to a meal, or follow the advice of you health care professional.

The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide medical advice to individuals. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.